Anti-Secretin/Sct Antibody , APC Conjugate

Boster Bio Anti-Secretin/Sct Antibody Picoband® catalog # A08899-1. Tested in ELISA, IHC applications. This antibody reacts with Mouse, Rat.

Product Specifications

Background

Secretin is a hormone that regulates water homeostasis throughout the body and influences the environment of the duodenum by regulating secretions in the stomach, pancreas, and liver. It is a peptide hormone produced in the S cells of the duodenum, which are located in the intestinal glands. In humans, the secretin peptide is encoded by the SCT gene. This gene encodes the precursor of a gastrointestinal peptide hormone of the secretin-glucagon family. The encoded protein is secreted as a prohormone that undergoes proteolytic processing to generate a mature peptide hormone. The mature peptide regulates secretion of gastric acid, biocarbonate ions from pancreatic and biliary duct epithelia and water homeostasis in the gastrointestinal system. Mice lacking the encoded protein display decreased survival of neuroprogenitor cells during early postnatal period and impaired long-term potentiation and spatial learning in adulthood. Alternative splicing results in multiple transcript variants encoding different isoforms. All of these isoforms may be processed in a similar manner to generate the mature peptide hormone.

Synonyms

Pannexin-2; PANX2

Gene Name

pannexin 2

Gene ID

20287

UniProt

Q08535

Host

Rabbit

Reactivity

Mouse,Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived mouse Secretin/Sct recombinant protein (Position: A25-D65).

Clonality

Polyclonal

Tissue Specificity

Expressed in fetal and adult brain. Also detected in fetal liver and skeletal muscle, but not in their adult counterparts.

Applications

IHC,ELISA

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Function

Structural component of the gap junctions and the hemichannels.

Components

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

References & Citations

1. Bayliss, W., Starling, E. H. The mechanism of pancreatic secretion. J. Physiol. (London) 28: 325-353, 1902. 2. Chu, J. Y. S., Chung, S. C. K., Lam, A. K. M., Tam, S., Chung, S. K., Chow, B. K. C. Phenotypes developed in secretin receptor-null mice indicated a role for secretin in regulating renal water reabsorption. Molec. Cell Biol. 27: 2499-2511, 2007. 3. Chu, J. Y. S., Lee, L. T. O., Lai, C. H., Vaudry, H., Chan, Y. S., Yung, W. H., Chow, B. K. C. Secretin as a neurohypophysial factor regulating body water homeostasis. Proc. Nat. Acad. Sci. 106: 15961-15966, 2009.

Storage Conditions

At -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freezing and thawing.