Anti-CINP Antibody Picoband®, APC Conjugate

Boster Bio Anti-CINP Antibody Picoband® catalog # A07687-1. Tested in Flow Cytometry, WB applications. This antibody reacts with Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Product Specifications

Background

Cartilage intermediate layer protein 1 is a protein that in humans is encoded by the CILP gene. The protein encoded by this gene is reported to be a component of the DNA replication complex as well as a genome-maintenance protein. It may interact with proteins important for replication initiation and has been shown to bind chromatin at the G1 phase of the cell cycle and dissociate from chromatin with replication initiation. It may also serve to regulate checkpoint signaling as part of the DNA damage response. Alternative splicing results in multiple transcript variants.

Synonyms

Trem-like transcript 1 protein;TLT-1;Triggering receptor expressed on myeloid cells-like protein 1;TREML1;TLT1;UNQ1825/PRO3438;

Gene Name

Trem-like transcript 1 protein

Gene ID

67236

UniProt

Q9D0V8

Host

Rabbit

Reactivity

Mouse

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of mouse CINP, which shares 85.7% and 100% amino acid (aa) sequence identity with human and rat CINP, respectively.

Clonality

Polyclonal

Tissue Specificity

Detected in platelets, monocytic leukemia and in T-cell leukemia. .

Applications

WB,Flow Cytometry

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Cell surface receptor that may play a role in the innate and adaptive immune response. .

Components

Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.01mg NaN3.

References & Citations

1. Grishina, I., Lattes, B. A novel Cdk2 interactor is phosphorylated by Cdc7 and associates with components of the replication complexes. Cell Cycle 4: 1120-1126, 2005. 2. Hartz, P. A. Personal Communication. Baltimore, Md. 4/15/2010. 3. Lovejoy, C. A., Xu, X., Bansbach, C. E., Glick, G. G., Zhao, R., Ye, F., Sirbu, B. M., Titus, L. C., Shyr, Y., Cortez, D. Functional genomic screens identify CINP as a genome maintenance protein. Proc. Nat. Acad. Sci. 106: 19304-19309, 2009.

Storage Conditions

Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

32679 MW

Observed Molecular Weight

26 kDa

Fragment

Rabbit IgG

Applications Notes

Western blot, 0.25-0.5μg/ml, Mouse<br> Flow Cytometry (Fixed), 1-3μg/1x10<sup>6</sup> cells, Mouse<br>

Subcellular Location

Cell membrane ; Single-pass type I membrane protein . Cytoplasm . Sequestered in cytoplasmic vesicles in resting platelets (PubMed:15100151). Transported to the cell surface after stimulation by thrombin (PubMed:15100151). Soluble fragments can be released into the serum by proteolysis (PubMed:16505478).