Anti-Wnt8a Antibody Picoband®, APC Conjugate

Boster Bio Anti-Wnt8a Antibody Picoband® catalog # A08392-2. Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Product Specifications

Background

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family, and may be implicated in development of early embryos as well as germ cell tumors. Multiple alternatively spliced transcript variants have been found for this gene.

Synonyms

Disintegrin and metalloproteinase domain-containing protein 2;ADAM 2;Cancer/testis antigen 15;CT15;Fertilin subunit beta;PH-30;PH30;PH30-beta;ADAM2;FTNB;

Gene Name

Disintegrin and metalloproteinase domain-containing protein 2

Gene ID

7478

UniProt

Q9H1J5

Host

Rabbit

Reactivity

Human,Mouse,Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human Wnt8a recombinant protein (Position: D206-S339).

Clonality

Polyclonal

Tissue Specificity

Expressed specifically in spermatogenic cells in the seminiferous cells. Not detected in fetal tissues.

Applications

WB,ELISA

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein.

Components

Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.01mg NaN3.

References & Citations

1. Janda, C. Y., Waghray, D., Levin, A. M., Thomas, C., Garcia, K. C. Structural basis of Wnt recognition by frizzled. Science 337: 59-64, 2012. 2. Saitoh, T., Katoh, M. Molecular cloning and characterization of human WNT8A. Int. J. Oncol. 19: 123-127, 2001. 3. Smith, J., Theodoris, C., Davidson, E. H. A gene regulatory network subcircuit drives a dynamic pattern of gene expression. Science 318: 794-797, 2007.

Storage Conditions

Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.