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Anti-Kallistatin/PI-4/SERPINA4 Antibody Picoband®, APC Conjugate

Boster Bio Anti-Kallistatin/PI-4/SERPINA4 Antibody Picoband® catalog # A08426. Tested in ELISA, IHC, WB applications. This antibody reacts with Human, Monkey, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Product Specifications

Background

Kallistatin is a protein that in humans is encoded by the SERPINA4 gene. It is mapped to 14q32.13. Serpin A4 is a member of the Serpin superfamily of the serine protease inhibitors. Known also as Kallistatin or proteinase inhibitor 4, Serpin A4 has been shown to function as a specific inhibitor of tissue kallikrein and as an inhibitor of angiogenesis and tumor growth.

Synonyms

Kallistatin; Kallikrein inhibitor; Peptidase inhibitor 4; PI-4; Serpin A4; SERPINA4; KST; PI4

Gene Name

serpin family A member 4

Gene ID

5267

UniProt

P29622

Host

Rabbit

Reactivity

Human,Monkey,Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human Kallistatin/PI-4/SERPINA4 recombinant protein (Position: H147-A373).

Clonality

Polyclonal

Tissue Specificity

Expressed by the liver and secreted in plasma.

Applications

WB,IHC,ELISA

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Inhibits human amidolytic and kininogenase activities of tissue kallikrein. Inhibition is achieved by formation of an equimolar, heat- and SDS-stable complex between the inhibitor and the enzyme, and generation of a small C-terminal fragment of the inhibitor due to cleavage at the reactive site by tissue kallikrein.

Components

Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na<sub>2</sub>HPO<sub>4</sub>, 0.05mg NaN<sub>3</sub>.

References & Citations

1. Chai, K. X., Chen, L.-M., Chao, J., Chao, L. Kallistatin: a novel human serine proteinase inhibitor: molecular cloning, tissue distribution, and expression in Escherichia coli. J. Biol. Chem. 268: 24498-24505, 1993. 2. Chai, K. X., Ward, D. C., Chao, J., Chao, L. Molecular cloning, sequence analysis, and chromosomal localization of the human protease inhibitor 4 (kallistatin) gene (PI4). Genomics 23: 370-378, 1994. 3. Miao, R. Q., Agata, J., Chao, L., Chao, J. Kallistatin is a new inhibitor of angiogenesis and tumor growth. Blood 100: 3245-3252, 2002.

Storage Conditions

Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

82457 MW

Observed Molecular Weight

49 kDa

Fragment

Rabbit IgG

Specificity

No cross reactivity with other proteins.

Applications Notes

Western blot, 0.25-0.5μg/ml, Monkey, Rat<br> Immunohistochemistry (Paraffin-embedded Section), 0.5-1μg/ml, Human<br> ELISA, 0.1-0.5μg/ml, -<br>

Subcellular Location

Secreted.

Protein Name

Disintegrin and metalloproteinase domain-containing protein 2

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