Anti-Polymeric immunoglobulin receptor/PIGR Picoband® Antibody, APC Conjugate

Boster Bio Anti-Polymeric immunoglobulin receptor/PIGR Picoband® Antibody catalog # A01624. Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Product Specifications

Background

Polymeric immunoglobulin receptor (pIgR) is a transmembrane protein that in humans is encoded by the PIGR gene. It is mapped to 1 E4; 1 56.89 cM. This gene is a member of the immunoglobulin superfamily. The encoded poly-Ig receptor binds polymeric immunoglobulin molecules at the basolateral surface of epithelial cells; the complex is then transported across the cell to be secreted at the apical surface. A significant association was found between immunoglobulin A nephropathy and several SNPs in this gene.

Synonyms

Polymeric immunoglobulin receptor; PIgR; Poly-Ig receptor; Secretory component; Pigr

Gene Name

polymeric immunoglobulin receptor

Gene ID

18703

UniProt

O70570

Host

Rabbit

Reactivity

Mouse,Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived mouse Polymeric immunoglobulin receptor/PIGR recombinant protein (Position: D34-A771).

Clonality

Polyclonal

Tissue Specificity

Expressed in all tissues examined.

Applications

ELISA,Flow Cytometry,WB

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment.

Components

Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

References & Citations

1. Davidson, M. K., Le Beau, M. M., Eddy, R. L., Shows, T. B., DiPietro, L. A., Kingzette, M., Hanly, W. C. Genetic mapping of the human polymeric immunoglobulin receptor gene to chromosome region 1q31-q41. Cytogenet. Cell Genet. 48: 107-111, 1988. 2. Hood, L., Kronenberg, M., Hunkapiller, T. T cell antigen receptors and the immunoglobulin supergene family. Cell 40: 225-229, 1985. 3. Krajci, P., Gedde-Dahl, T., Jr., Hoyheim, B., Rogde, S., Olaisen, B., Brandtzaeg, P. The gene encoding human transmembrane secretory component (locus PIGR) is linked to D1S58 on chromosome 1. Hum. Genet. 90: 215-219, 1992.

Storage Conditions

Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.