Anti-Factor D/CFD Antibody Picoband® (APC Conjugate)

Factor D is a?protein?which in humans is encoded by the?CFD?gene. The protein encoded by this gene is a member of the?trypsin?family of peptidases. The encoded protein is a component of the?alternative complement pathway?best known for its role in humoral suppression of infectious agents. It is also a serine protease that is secreted by?adipocytes?into the bloodstream. And it stimulates glucose transport for triglyceride accumulation in fats cells and inhibits lipolysis. Finally, the encoded protein has a high level of expression in fat, suggesting a role for adipose tissue in immune system biology.

E. coli-derived mouse Factor D recombinant protein (Position: Q30-K235). Mouse Factor D shares 66.5% and 87.4% amino acid (aa) sequence identity with human and rat Factor D, respectively.

Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway.

Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.