Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-Fas Antibody Picoband® (APC Conjugate)

Boster Bio Anti-Fas Antibody Picoband® catalog # PB9252. Tested in IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Product Specifications

Background

FAS (also known as surface antigen APO1 or CD95) is a member of the tumour-necrosis receptor factor family of death receptors. It acts as an inducer of both neurite growth in vitro and accelerated recovery after nerve injury in vivo. FAS antigen is expressed and functional on papillary thyroid cancer cells and this may have potential therapeutic significance. The FAS antigen shows structural homology with a number of cell surface receptors, including tumor necrosis factor (TNF) receptors and the low-affinity nerve growth factor receptor (NGFR) and it is mapped to 10q24.1. The FAS and FASL system plays a key role in regulating apoptotic cell death and corruption of this signalling pathway has been shown to participate in immune escape and tumorigenesis.

Synonyms

Tumor necrosis factor receptor superfamily member 6;Apo-1 antigen;Apoptosis-mediating surface antigen FAS;FASLG receptor;CD95;FAS;APT1, FAS1, TNFRSF6;

Gene Name

Tumor necrosis factor receptor superfamily member 6

UniProt

P25445

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E.coli-derived human Fas recombinant protein (Position: Q26-N173). Human Fas shares 55% and 59% amino acid (aa) sequences identity with mouse and rat Fas, respectively.

Clonality

Polyclonal

Tissue Specificity

Isoform 1 and isoform 6 are expressed at equal levels in resting peripheral blood mononuclear cells. After activation there is an increase in isoform 1 and decrease in the levels of isoform 6. .

Applications

IHC,WB

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death- inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS- mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro). .

Storage Conditions

Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=PB9252

Product MSDS

https://www.bosterbio.com/msds?sku=PB9252

Fragment

Rabbit IgG

Applications Notes

Immunohistochemistry (Paraffin-embedded Section), 0.5-1μg/ml, Human, By Heat <br>Western blot, 0.1-0.5μg/ml, Human<br>

Subcellular Location

Isoform 1: Cell membrane; Single-pass type I membrane protein.

Sequence Similarities

Contains 1 death domain.

Protein Name

Tumor necrosis factor receptor superfamily member 6

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

Rabbit Polyclonal Casein Kinase 1 gamma Antibody
NBP2-32245 100 µL

Rabbit Polyclonal Casein Kinase 1 gamma Antibody

Ask
View Details
Recombinant Human Cytokine receptor-like factor 2 (CRLF2), partial, Biotinylated (Active)
CSB-MP005983HU-B-01 20 µg

Recombinant Human Cytokine receptor-like factor 2 (CRLF2), partial, Biotinylated (Active)

Ask
View Details
Recombinant Human Cytokine receptor-like factor 2 (CRLF2), partial, Biotinylated (Active)
CSB-MP005983HU-B-02 100 µg

Recombinant Human Cytokine receptor-like factor 2 (CRLF2), partial, Biotinylated (Active)

Ask
View Details
Recombinant Human Cytokine receptor-like factor 2 (CRLF2), partial, Biotinylated (Active)
CSB-MP005983HU-B-03 1 mg

Recombinant Human Cytokine receptor-like factor 2 (CRLF2), partial, Biotinylated (Active)

Ask
View Details
Mouse Anti-Pig IgG H&L Antibody (AF680)
abx142846-01 100 µL

Mouse Anti-Pig IgG H&L Antibody (AF680)

Ask
View Details
Mouse Anti-Pig IgG H&L Antibody (AF680)
abx142846-02 500 µL

Mouse Anti-Pig IgG H&L Antibody (AF680)

Ask
View Details