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Anti-PXK Antibody Picoband®, FITC Conjugate

Boster Bio Anti-PXK Antibody Picoband® catalog # A07555-1. Tested in ELISA, IF, ICC, WB applications. This antibody reacts with Human, Monkey. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Product Specifications

Background

PX domain containing serine/threonine kinase also known as PXK is a protein which in humans is encoded by the PXK gene. This gene encodes a phox (PX) domain-containing protein which may be involved in synaptic transmission and the ligand-induced internalization and degradation of epidermal growth factors. Variations in this gene may be associated with susceptibility to systemic lupus erythematosus (SLE). Alternative splicing results in multiple transcript variants.

Synonyms

C-C motif chemokine 16; Chemokine CC-4; HCC-4; Chemokine LEC; IL-10-inducible chemokine; LCC-1; Liver-expressed chemokine; Lymphocyte and monocyte chemoattractant; LMC; Monotactin-1; MTN-1; NCC-4; Small-inducible cytokine A16; CCL16; ILINCK; NCC4; SCYA16

Gene Name

C-C motif chemokine ligand 16

Gene ID

54899

UniProt

Q7Z7A4

Host

Rabbit

Reactivity

Human,Monkey

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human PXK recombinant protein (Position: E5-K576).

Clonality

Polyclonal

Tissue Specificity

Mainly expressed in liver, also found in spleen and thymus. Highly expressed in LPS- and IFN-gamma- activated monocytes, weakly in some lymphocytes, including natural killer cells, gamma-delta T-cells, and some T-cell clones.

Applications

ELISA,IF,ICC,WB

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Function

Shows chemotactic activity for lymphocytes and monocytes but not neutrophils. Also shows potent myelosuppressive activity, suppresses proliferation of myeloid progenitor cells. Recombinant SCYA16 shows chemotactic activity for monocytes and THP-1 monocytes, but not for resting lymphocytes and neutrophils. Induces a calcium flux in THP-1 cells that were desensitized by prior expression to RANTES.

Components

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

References & Citations

1. Mao, H., Ferguson, T. S., Cibulsky, S. M., Holmqvist, M., Ding, C., Fei, H., Levitan, I. B. MONaKA, a novel modulator of the plasma membrane Na,K-ATPase. J. Neurosci. 25: 7934-7943, 2005. 2. Zou, X., Qiu, G., Chen, C., Wu, M., Hu, Y., Zheng, H., Li, X., Gu, S., Ji, C., Mao, Y. Expression pattern and subcellular localization of five splice isoforms of human PXK. Int. J. Molec. Med. 16: 701-707, 2005.

Storage Conditions

At -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freezing and thawing.

Calculated Molecular Weight

157578 MW

Observed Molecular Weight

65 kDa

Fragment

Rabbit IgG

Applications Notes

Western blot, 0.1-0.25 μg/ml, Human, Monkey<br> Immunocytochemistry/Immunofluorescence, 5 μg/ml, Human<br> ELISA, 0.1-0.5 μg/ml, -<br>

Subcellular Location

Secreted.

Protein Name

BAG family molecular chaperone regulator 5

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