Rimantadine (hydrochloride)

Rimantadine hydrochloride (Flumadine hydrochloride) is an orally active inhibitor for M2 protein, that blocks the hydrogen ion channel activity, prevents the entry and replication of the virus, and exhibits board-spectrum antiviral activity[1].

Product Specifications

CAS Number

[1501-84-4]

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Autophagy; Influenza Virus

Type

Reference compound

Related Pathways

Anti-infection; Autophagy

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/Rimantadine-hydrochloride.html

Purity

98.0

Solubility

DMSO : 50 mg/mL (ultrasonic) |H2O : 33.33 mg/mL (ultrasonic)

Smiles

CC(C1(C[C@H](C2)C3)C[C@H]3C[C@H]2C1)N.Cl

Molecular Formula

C12H22ClN

Molecular Weight

215.76

Precautions

H302, H315, H319, H335

References & Citations

[1]Sasaki-Tanaka R, et al., Amantadine and Rimantadine Inhibit Hepatitis A Virus Replication through the Induction of Autophagy. J Virol. 2022 Sep 28;96 (18) :e0064622.|[2]Simeonova L, et al., Prophylactic and therapeutic combination effects of rimantadine and oseltamivir against influenza virus A (H3N2) infection in mice. Antiviral Res. 2012 Aug;95 (2) :172-81.