PKM2 activator 2
PKM2 activator 2 (compound 28) is a pyruvate kinase M2 (PKM2) activitor with an AC50 value of 66 nM. PKM2 activator 2 can restore normal glycolytic metabolism in cells[1].
Product Specifications
CAS Number
[1186660-06-9]
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Pyruvate Kinase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pkm2-activator-2.html
Purity
99.38
Solubility
DMSO : 5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
FC1=C(S(=O)(N2CCN(S(=O)(C3=CC4=C(C=CC=C4)C=C3)=O)CC2)=O)C(F)=CC=C1
Molecular Formula
C20H18F2N2O4S2
Molecular Weight
452.49
Precautions
H302, H315, H319
References & Citations
[1]Boxer MB, et al. Evaluation of substituted N, N'-diarylsulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase. J Med Chem. 2010 Feb 11;53 (3) :1048-55.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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