BuChE-IN-11

BuChE-IN-11 (Compound 3b-1) is an selective BuChE inhibitor with an IC50 of 0.44 μM for hBuChE. BuChE-IN-11 has high blood-brain barrier permeability and exhibits strong antioxidant activity due to its free radical scavenging properties. BuChE-IN-11 interacts with the choline binding site, acetyl binding site, and peripheral anionic site, exhibiting submicromolar BuChE inhibitory activity and preventing β-amyloid (Aβ) self-aggregation. BuChE-IN-11 holds promise for research in the field of Alzheimer's disease[1].

Product Specifications

UNSPSC

12352005

Target

Cholinesterase (ChE)

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/buche-in-11.html

Smiles

O=C(NCCC1=CNC2=C1C=CC=C2)[C@@H](NCC3=CC=C(O)C(F)=C3)CC4=CNC5=C4C=CC=C5

Molecular Formula

C28H27FN4O2

Molecular Weight

470.54

References & Citations

[1]Zeng X, et al. Design, synthesis, and activity evaluation of novel multitargeted l‐tryptophan derivatives with powerful antioxidant activity against Alzheimer's disease[J]. Archiv der Pharmazie, 2024: e2300603.