AA147

AA147 is a endoplasmic reticulum (ER) proteostasis regulator. AA147 promotes protection against oxidative damage in neuronal cells and prevents endothelial barrier dysfunction by activating ATF6 arm (selectively) of the unfolded protein response (UPR) and the NRF2 oxidative stress response. AA147 can rebalances XBP1s expression in vivo, and also induces survival motor neuron (SMN) expression and spinal motorneuron (MN) protection[1][2][3][4].

Product Specifications

CAS Number

[393121-74-9]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

ATF6; Reactive Oxygen Species (ROS)

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/aa147.html

Purity

99.81

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(NC1=CC(C)=CC=C1O)CCC2=CC=CC=C2

Molecular Formula

C16H17NO2

Molecular Weight

255.31

Precautions

H302, H315, H319, H335

References & Citations

[1]Christina COOLEY, et al. Regulators of the endoplasmic reticulum proteostasis network. WO2017117430A1.|[2]Rosarda JD, et al. Metabolically Activated Proteostasis Regulators Protect against Glutamate Toxicity by Activating NRF2. ACS Chem Biol. 2021 Dec 17;16 (12) :2852-2863. |[3]Kubra KT, et al. Activating transcription factor 6 protects against endothelial barrier dysfunction. Cell Signal. 2022 Aug 4;99:110432. |[4]D'Amico D, et al. Activating ATF6 in spinal muscular atrophy promotes SMN expression and motor neuron survival through the IRE1α-XBP1 pathway. Neuropathol Appl Neurobiol. 2022 Aug;48 (5) :e12816.