Anti-TNFRSF18 Antibody Picoband® (FITC Conjugate)

Tumor necrosis factor receptor superfamily member 18 (TNFRSF18), also called GITR or AITR is a protein that in humans is encoded by the TNFRSF18 gene. It is mapped to 1p36.33. This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25 (+)CD4 (+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Tumor necrosis factor receptor superfamily member 18;Activation-inducible TNFR family receptor;Glucocorticoid-induced TNFR-related protein;CD357;TNFRSF18;AITR, GITR;UNQ319/PRO364;

E. coli-derived human TNFRSF18 recombinant protein (Position: L178-V241). Human TNFRSF18 shares 76.2% amino acid (aa) sequence identity with mouse TNFRSF18.

Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway.

Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.