Sofpironium (tosylate)

Sofpironium (BBI 4000) tosylate is an anticholinergic agent used in the study of primary axillary hyperhidrosis (PAH) . Sofpironium tosylate reduces sweating by inhibiting M3 muscarinic receptors in eccrine glands at the application site. Sofpironium tosylate also has a high afnity for the M1, M2, M4 and M5 subtypes[1].

Product Specifications

CAS Number

[2409055-48-5]

Product Name Alternative

BBI-4000 (tosylate)

UNSPSC

12352005

Target

MAChR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/sofpironium-tosylate.html

Smiles

O=S([O-])(C1=CC=C(C=C1)C)=O.CCOC(C[N+](C)(CC2)C[C@@H]2OC([C@@](C3CCCC3)(C4=CC=CC=C4)O)=O)=O

Molecular Formula

C29H39NO8S

Molecular Weight

561.69

References & Citations

[1]Julia Paik, et al. Sofpironium Bromide: First Approval. Drugs. 2020 Dec;80 (18) :1981-1986.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

Phase 3

Isoform

MAChR1; mAChR2; mAChR3; mAChR4; mAChR5

Curated Selection

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