Sofpironium (tosylate)
Sofpironium (BBI 4000) tosylate is an anticholinergic agent used in the study of primary axillary hyperhidrosis (PAH) . Sofpironium tosylate reduces sweating by inhibiting M3 muscarinic receptors in eccrine glands at the application site. Sofpironium tosylate also has a high afnity for the M1, M2, M4 and M5 subtypes[1].
Product Specifications
CAS Number
[2409055-48-5]
Product Name Alternative
BBI-4000 (tosylate)
UNSPSC
12352005
Target
MAChR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/sofpironium-tosylate.html
Smiles
O=S([O-])(C1=CC=C(C=C1)C)=O.CCOC(C[N+](C)(CC2)C[C@@H]2OC([C@@](C3CCCC3)(C4=CC=CC=C4)O)=O)=O
Molecular Formula
C29H39NO8S
Molecular Weight
561.69
References & Citations
[1]Julia Paik, et al. Sofpironium Bromide: First Approval. Drugs. 2020 Dec;80 (18) :1981-1986.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
MAChR1; mAChR2; mAChR3; mAChR4; mAChR5
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