Pteroylhexaglutamate

Pteroylhexaglutamate (PteGlu6) inhibits the T2-phage-induced synthetase by 50% at 0.6 μM in the absence of Mg2+. Pteroylhexaglutamate is a substrate for pteroylpolyglutamate hydrolase, and can be used to monitor the activity of pteroylpolyglutamate hydrolase[1][2].

Product Specifications

CAS Number

[35409-55-3]

Product Name Alternative

PteGlu6

UNSPSC

12352005

Target

Endogenous Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/pteroylhexaglutamate.html

Purity

96.69

Smiles

O=C1C2=NC(CNC(C=C3)=CC=C3C(N[C@H](C(O)=O)CCC(N[C@H](C(O)=O)CCC(N[C@H](C(O)=O)CCC(N[C@H](C(O)=O)CCC(N[C@H](C(O)=O)CCC(N[C@H](C(O)=O)CCC(O)=O)=O)=O)=O)=O)=O)=O)=CNC2=NC(N)=N1

Molecular Formula

C44H54N12O21

Molecular Weight

1086.97

References & Citations

[1]Maley GF, et al. Differential inhibition of host and viral thymidylate synthetases by folylpolyglutamates. J Biol Chem. 1979 Aug 25;254 (16) :7485-7. |[2]Seyoum E, et al. Properties of food folates determined by stability and susceptibility to intestinal pteroylpolyglutamate hydrolase action. J Nutr. 1998 Nov;128 (11) :1956-60.