Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-MCL1 Antibody Picoband® (HRP Conjugate)

Boster Bio Anti-MCL1 Antibody Picoband® catalog # PB9132. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Product Specifications

Background

MCL1, also known as myeloid cell leukemia 1, is a protein that in humans is encoded the MCL1 gene. It is mapped to 1q21.3. MCL1 is a potent multidomain antiapoptotic protein of the BCL2 family that heterodimerizes with other BCL2 family members to protect against apoptotic cell death. MCL1 as an attractive candidate for regulation of hematopoietic stem cell homeostasis that is highly expressed in hematopoietic stem cells and regulated by growth factor signals. MCL1 is a critical and specific regulator essential for ensuring the homeostasis of early hematopoietic progenitors. During mitotic arrest, MCL1 protein levels decline markedly, through a posttranslational mechanism, potentiating cell death. Phosphorylation of MCL1 s its interaction with the tumor suppressor protein FBW7, which is the substrate-binding component of a ubiquitin ligase complex.

Synonyms

Induced myeloid leukemia cell differentiation protein Mcl-1;Bcl-2-like protein 3;Bcl2-L-3;Bcl-2-related protein EAT/mcl1;mcl1/EAT;MCL1;BCL2L3;

Gene Name

Induced myeloid leukemia cell differentiation protein Mcl-1

UniProt

Q07820

Host

Rabbit

Reactivity

Human,Mouse,Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E.coli-derived human MCL1 recombinant protein (Position: M1-R350). Human MCL1 shares 82% and 78% amino acid (aa) sequences identity with mouse and rat MCL1, respectively.

Clonality

Polyclonal

Tissue Specificity

Ubiquitously expressed, with more abundant expression in the brain.

Applications

IHC,WB

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis. .

Storage Conditions

Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=PB9132

Product MSDS

https://www.bosterbio.com/msds?sku=PB9132

Fragment

Rabbit IgG

Applications Notes

Immunohistochemistry (Paraffin-embedded Section), 0.5-1μg/ml, Human, Mouse, Rat, By Heat<br>Western blot, 0.1-0.5μg/ml, Human, Rat<br>

Subcellular Location

Membrane ; Single-pass membrane protein . Cytoplasm. Mitochondrion. Nucleus, nucleoplasm. Cytoplasmic, associated with mitochondria.

Sequence Similarities

Belongs to the Bcl-2 family.

Protein Name

Induced myeloid leukemia cell differentiation protein Mcl-1

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

N-Carbobenzoxy-L-tryptophan-p-nitrophenyl ester
C04380 100 g

N-Carbobenzoxy-L-tryptophan-p-nitrophenyl ester

Ask
View Details
TBS Buffer 20X with 2% Tween 20
42020413-3 4 L

TBS Buffer 20X with 2% Tween 20

Ask
View Details
DSG3 Antibody
E19-9439-1 50ug/50ul

DSG3 Antibody

Ask
View Details
CYB561D2 (C-2) Alexa Fluor® 546
sc-373870 AF546 200 µg/mL

CYB561D2 (C-2) Alexa Fluor® 546

Ask
View Details
RANK Rabbit pAb
MBS8540569-01 0.1 mL

RANK Rabbit pAb

Ask
View Details
RANK Rabbit pAb
MBS8540569-02 0.1 mL (AF405L)

RANK Rabbit pAb

Ask
View Details