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Anti-Prostaglandin E Receptor EP1/PTGER1 Antibody Picoband®, PE Conjugate

Boster Bio Anti-Prostaglandin E Receptor EP1/PTGER1 Antibody catalog # PA1583. Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Product Specifications

Background

PTGER1, Prostaglandin E Receptor 1, comprises 402 amino acids with a predicted molecular mass of 41, 858 and has the 7 predicted transmembrane-spanning domains common to all G protein-coupled receptors. The PTGER1 gene is mapped to chromosome 19p13.1. The protein encoded by this gene is a member of the G protein-coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). Through a phosphatidylinositol-calcium second messenger system, Gq proteins mediate this receptor's activity. Knockout studies in mice suggested a role of this receptor in mediating algesia and in regulation of blood pressure. Studies in mice also suggested that this gene may mediate adrenocorticotropic hormone response to bacterial endotoxin.

Synonyms

Prostaglandin E2 receptor EP1 subtype;PGE receptor EP1 subtype;PGE2 receptor EP1 subtype;Prostanoid EP1 receptor;PTGER1;

Gene Name

Prostaglandin E2 receptor EP1 subtype

UniProt

P34995

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human Prostaglandin E Receptor EP1.

Clonality

Polyclonal

Tissue Specificity

Abundant in kidney. Lower level expression in lung, skeletal muscle and spleen, lowest expression in testis and not detected in liver brain and heart.

Applications

WB

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G (q) proteins which activate a phosphatidylinositol-calcium second messenger system. May play a role as an important modulator of renal function. Implicated the smooth muscle contractile response to PGE2 in various tissues.

Components

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

References & Citations

1. Funk, C. D., Furci, L., FitzGerald, G. A., Grygorczyk, R., Rochette, C., Bayne, M. A., Abramovitz, M., Adam, M., Metters, K. M.Cloning and expression of a cDNA for the human prostaglandin E receptor EP-1 subtype.J. Biol. Chem. 268: 26767-26772, 1993. 2. Matsuoka, Y., Furuyashiki, T., Yamada, K., Nagai, T., Bito, H., Tanaka, Y., Kitaoka, S., Ushikubi, F., Nabeshima, T., Narumiya, S.Prostaglandin E receptor E1 controls impulsive behavior under stress.Proc. Nat. Acad. Sci. 102: 16066-16071, 2005 3. Stock, J. L., Shinjo, K., Burkhardt, J., Roach, M., Taniguchi, K., Ishikawa, T., Kim, H.-S., Flannery, P. J., Coffman, T. M., McNeish, J. D., Audoly, L. P.The prostaglandin E2 EP1 receptor mediates pain perception and regulates blood pressure.J. Clin. Invest. 107: 325-331, 2001.

Storage Conditions

Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=PA1583

Product MSDS

https://www.bosterbio.com/msds?sku=PA1583

Calculated Molecular Weight

41801 MW

Observed Molecular Weight

42 kDa

Fragment

Rabbit IgG

Specificity

No cross reactivity with other proteins.

Applications Notes

Western blot, 0.1-0.5μg/ml, Human<br>

Subcellular Location

Cell membrane; Multi-pass membrane protein.

Sequence Similarities

Belongs to the G-protein coupled receptor 1 family.

Protein Name

Prostaglandin E2 receptor EP1 subtype(PGE receptor EP1 subtype/PGE2 receptor EP1 subtype)

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