Anti-GIPC3 Antibody Picoband®, PE Conjugate

PDZ domain-containing protein GIPC3 is a protein that in humans is encoded by the GIPC3 gene. The protein encoded by this gene belongs to the GIPC family. Studies in mice suggest that this gene is required for postnatal maturation of the hair bundle and long-term survival of hair cells and spiral ganglion in the ear. Mutations in this gene are associated with autosomal recessive deafness.

1. Ain, Q., Nazli, S., Riazuddin, S., Jaleel, A., Riazuddin, S. A., Zafar, A. U., Khan, S. N., Husnain, T., Griffith, A. J., Ahmed, Z. M., Friedman, T. B., Riazuddin, S. The autosomal recessive nonsyndromic deafness locus DFNB72 is located on chromosome 19p13.3. Hum. Genet. 122: 445-450, 2007. 2. Charizopoulou, N., Lelli, A., Schraders, M., Ray, K., Hildebrand, M. S., Ramesh, A., Srisailapathy, C. R., Oostrik, J., Admiraal, R. J. C., Neely, H. R., Latoche, J. R., Smith, R. J. H., Northup, J. K., Kremer, H., Holt, J. R., Noben-Trauth, K. Gipc3 mutations associated with audiogenic seizures and sensorineural hearing loss in mouse and human. Nature Commun. 2: 201, 2011. Note: Electronic Article. 3. Chen, A., Wayne, S., Bell, A., Ramesh, A., Srisailapathy, C. R., Scott, D. A., Sheffield, V. C., Van Hauwe, P., Zbar, R. I., Ashley, J., Lovett, M., Van Camp, G., Smith, R. J. New gene for autosomal recessive non-syndromic hearing loss maps to either chromosome 3q or 19p. Am. J. Med. Genet. 71: 467-471, 1997.

At -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freezing and thawing.

Western blot, 0.25-0.5 μg/ml, Human, Rat<br> Immunocytochemistry/Immunofluorescence, 5 μg/ml, Human<br> Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human<br> ELISA, 0.1-0.5 μg/ml, -<br>