Anti-PRODH Antibody Picoband®, PE Conjugate

Boster Bio Anti-PRODH Antibody Picoband® catalog # A03231-3. Tested in ELISA, IHC, WB, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Product Specifications

Background

Proline dehydrogenase, mitochondrial is an enzyme that in humans is encoded by the PRODH gene. This gene encodes a mitochondrial protein that catalyzes the first step in proline degradation. Mutations in this gene are associated with hyperprolinemia type 1 and susceptibility to schizophrenia 4 (SCZD4). This gene is located on chromosome 22q11.21, a region which has also been associated with the contiguous gene deletion syndromes, DiGeorge and CATCH22. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Synonyms

Peptidyl-prolyl cis-trans isomerase B; PPIase B; 5.2.1.8; CYP-S1; Cyclophilin B; Rotamase B; S-cyclophilin; SCYLP; PPIB; CYPB;

Gene Name

peptidylprolyl isomerase B

Gene ID

5625

UniProt

O43272

Host

Rabbit

Reactivity

Human,Mouse,Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human PRODH recombinant protein (Position: H116-E433).

Clonality

Polyclonal

Tissue Specificity

Found mainly in the liver, kidney and skeletal muscle.

Applications

WB,IHC,Flow Cytometry,ELISA

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Function

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

Components

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

References & Citations

1. Afenjar, A., Moutard, M.-L., Doummar, D., Guet, A., Rabier, D., Vermersch, A.-I., Mignot, C., Burglen, L., Heron, D., Thioulouse, E., de Villemeur, T. B., Campion, D., Rodriguez, D. Early neurological phenotype in 4 children with biallelic PRODH mutations. Brain Dev. 29: 547-552, 2007. 2. Baron, M. Genetics of schizophrenia and the new millennium: progress and pitfalls. Am. J. Hum. Genet. 68: 299-312, 2001. 3. Bender, H.-U., Almashanu, S., Steel, G., Hu, C.-A., Lin, W.-W., Willis, A., Pulver, A., Valle, D. Functional consequences of PRODH missense mutations. Am. J. Hum. Genet. 76: 409-420, 2005.

Storage Conditions

At -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freezing and thawing.

Calculated Molecular Weight

37836 MW

Observed Molecular Weight

69 kDa

Fragment

Rabbit IgG

Applications Notes

Western blot, 0.25-0.5 μg/ml, Mouse, Rat Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/ml, Human Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human ELISA, 0.1-0.5 μg/ml, -