Anti-RAB36 Antibody Picoband®, PE Conjugate

Boster Bio Anti-RAB36 Antibody Picoband® catalog # A14616-1. Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Product Specifications

Background

Ras-related protein Rab-36 is a protein that in humans is encoded by the RAB36 gene. The Ras-related superfamily of guanine nucleotide binding proteins includes the R-Ras, Rap, Ral/Rec and Rho/Rab subfamilies. Increasing data suggests an important role for Rab proteins in either endocytosis or in biosynthetic protein transport. The process of transporting newly synthesized proteins from the endoplasmic reticulum to various stacks of the Golgi complex and to secretory vesicles involves the movement of carrier vesicles and requires Rab protein function. Rab proteins are also an integral part of endocytic pathways. Rab 36 is a ubiquitously expressed member of the Rab family of proteins and localizes to the Golgi membrane where it is believed to participate in protein transport. The gene encoding Rab 36 localizes to a critical region of chromosome 22 that is often deleted or involved in translocations in malignant rhabdoid tumors (MRTs). This suggests that Rab 36 may play a role in the development of MRTs.

Synonyms

DAP3-binding cell death enhancer 1; Death ligand signal enhancer; DELE1; DELE; KIAA0141

Gene Name

DAP3 binding cell death enhancer 1

Gene ID

9609

UniProt

O95755

Host

Rabbit

Reactivity

Human,Mouse,Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human RAB36 recombinant protein (Position: Q56-E323).

Clonality

Polyclonal

Tissue Specificity

Detected in liver, skeletal muscle, kidney, pancreas, spleen, thyroid, testis, ovary, small intestine and colon.

Applications

WB,ELISA

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Function

Essential for the induction of death receptor-mediated apoptosis through the regulation of caspase activation.

Components

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

References & Citations

1. Mori, T., Fukuda, Y., Kuroda, H., Matsumura, T., Ota, S., Sugimoto, T., Nakamura, Y., Inazawa, J. Cloning and characterization of a novel Rab-family gene, Rab36, within the region at 22q11.2 that is homozygously deleted in malignant rhabdoid tumors. Biochem. Biophys. Res. Commun. 254: 594-600, 1999. 2. Zhou, J.-Y., Fogelgren, B., Wang, Z., Roe, B. A., Biegel, J. A. Isolation of genes from the rhabdoid tumor deletion region in chromosome band 22q11.2. Gene 241: 133-141, 2000.

Storage Conditions

At -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freezing and thawing.