MDL-29951

MDL-29951 is a novel glycine antagonist of NMDA receptor activation, with Ki of 0.14 μM for [3H]glycine binding in vitro and in vivo.

Product Specifications

CAS Number

[130798-51-5]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

IGluR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/mdl-29951.html

Purity

99.17

Solubility

DMSO : ≥ 50 mg/mL

Smiles

O=C(O)CCC1=C(C(O)=O)NC2=C1C(Cl)=CC(Cl)=C2

Molecular Formula

C12H9Cl2NO4

Molecular Weight

302.11

Precautions

H302, H315, H319, H335

References & Citations

[1]Baron BM, et al. Potent indole- and quinoline-containing N-methyl-D-aspartate antagonists acting at the strychnine-insensitive glycine binding site. J Pharmacol Exp Ther. 1992 Sep;262 (3) :947-56.|[2]Wright SW, et al. 3- (2-carboxyethyl) -4,6-dichloro-1H-indole-2-carboxylic acid: an allosteric inhibitor of fructose-1,6-bisphosphatase at the AMP site. Bioorg Med Chem Lett. 2003 Jun 16;13 (12) :2055-8.|[3]Harden TK. Enigmatic GPCR finds a stimulating drug. Sci Signal. 2013 Oct 22;6 (298) :pe34.