Coumarin 6

Coumarin 6, a fluorescent dye, is used as a fluorescent probe in a microparticle drug delivery system to conduct in vivo tracking, cell uptake, and transport mechanism studies of drug delivery systems (λexc=450 nm, λem=505 nm) [1][2][3].

Product Specifications

CAS Number

[38215-36-0]

UNSPSC

12171500

Hazard Statement

H315, H319

Target

Fluorescent Dye

Type

Dye Reagents

Related Pathways

Others

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/coumarin-6.html

Concentration

10mM

Purity

99.72

Solubility

DMSO : 5 mg/mL (ultrasonic; warming; heat to 60°C) |THF : 12.5 mg/mL (ultrasonic)

Smiles

O=C1C(C2=NC3=CC=CC=C3S2)=CC4=CC=C(N(CC)CC)C=C4O1

Molecular Formula

C20H18N2O2S

Molecular Weight

350.44

Precautions

H315, H319

References & Citations

[1]Purr E, et al. Preparation of PLGA Nanoparticles Encapsulated with Fluorescent Probe Coumarin-6[J]. bioRxiv, 2019: 614875.|[2]Rivolta I, et al. Cellular uptake of coumarin-6 as a model drug loaded in solid lipid nanoparticles. J Physiol Pharmacol. 2011 Feb;62 (1) :45-53. |[3]Miao X, et al. Transport Mechanism of Coumarin 6 Nanocrystals with Two Particle Sizes in MDCKII Monolayer and Larval Zebrafish. ACS Appl Mater Interfaces. 2016 May 25;8 (20) :12620-30.