Anti-GFPT1 Antibody Picoband®, PE Conjugate

Glucosamine—fructose-6-phosphate aminotransferase isomerizing 1 is an enzyme that in humans is encoded by the GFPT1 gene. This gene encodes the first and rate-limiting enzyme of the hexosamine pathway and controls the flux of glucose into the hexosamine pathway. The product of this gene catalyzes the formation of glucosamine 6-phosphate.

1. Helman, G., Sharma, S., Crawford, J., Patra, B., Jain, P., Bent, S. J., Urtizberea, J. A., Saran, R. K., Taft, R. J., van der Knaap, M. S., Simons, C. Leukoencephalopathy due to variants in GFPT1-associated congenital myasthenic syndrome. Neurology 92: e587-e593, 2019. Note: Electronic Article. 2. Issop, Y., Hathazi, D., Khan, M. M., Rudolf, R., Weis, J., Spendiff, S., Slater, C. R., Roos, A., Lochmuller, H. GFPT1 deficiency in muscle leads to myasthenia and myopathy in mice. Hum. Molec. Genet. 27: 3218-3232, 2018. 3. McKnight, G. L., Mudri, S. L., Mathewes, S. L., Traxinger, R. R., Marshall, S., Sheppard, P. O., O'Hara, P. J. Molecular cloning, cDNA sequence, and bacterial expression of human glutamine:fructose-6-phosphate amidotransferase. J. Biol. Chem. 267: 25208-25212, 1992.

At -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freezing and thawing.

Western blot, 0.25-0.5 μg/ml, Human<br> Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/ml, Human<br> Immunocytochemistry/Immunofluorescence, 5 μg/ml, Human<br> Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human, Rat<br>