Anti-REG1A/1B Antibody Picoband®, PE Conjugate

Boster Bio Anti-REG1A/1B Antibody Picoband® catalog # A03075-2. Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Product Specifications

Background

This gene is a type I subclass member of the Reg gene family. The Reg gene family is a multigene family grouped into four subclasses, types I, II, III and IV, based on the primary structures of the encoded proteins. This gene encodes a protein that is secreted by the exocrine pancreas. It is associated with islet cell regeneration and diabetogenesis and may be involved in pancreatic lithogenesis. Reg family members REG1B, REGL, PAP and this gene are tandemly clustered on chromosome 2p12 and may have arisen from the same ancestral gene by gene duplication.

Synonyms

Metastasis-associated protein MTA2; Metastasis-associated 1-like 1; MTA1-L1 protein; p53 target protein in deacetylase complex; MTA2; MTA1L1; PID

Gene Name

metastasis associated 1 family member 2

Gene ID

5967/5968

UniProt

P05451/P48304

Host

Rabbit

Reactivity

Human,Mouse,Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human REG1A/1B recombinant protein (Position: N51-E90).

Clonality

Polyclonal

Tissue Specificity

Expressed in skeletal muscle, kidney, heart, placenta, liver, thymus, lung, and ovary, with little or no expression in other tissues.

Applications

WB,ELISA

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Function

May be involved in the regulation of gene expression as repressor and activator. The repression might be related to covalent modification of histone proteins.

Components

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

References & Citations

1. Acquatella-Tran Van Ba, I., Marchal, S., Francois, F., Silhol, M., Lleres, C., Michel, B., Benyamin, Y., Verdier, J.-M., Trousse, F., Marcilhac, A. Regenerating islet-derived 1-alpha (Reg-1-alpha) protein is new neuronal secreted factor that stimulates neurite outgrowth via exostosin tumor-like 3 (EXTL3) receptor. J. Biol. Chem. 287: 4726-4739, 2012. 2. Akiyama, T., Takasawa, S., Nata, K., Kobayashi, S., Abe, M., Shervani, N. J., Ikeda, T., Nakagawa, K., Unno, M., Matsuno, S., Okamoto, H. Activation of Reg gene, a gene for insulin-producing beta-cell regeneration: poly(ADP-ribose) polymerase binds Reg promoter and regulates the transcription by autopoly(ADP-ribosyl)ation. Proc. Nat. Acad. Sci. 98: 48-53, 2001. 3. Bartoli, C., Gharib, B., Giorgi, D., Sansonetti, A., Dagorn, J.-C., Berge-Lefranc, J.-L. A gene homologous to the reg gene is expressed in human pancreas. FEBS Lett. 327: 289-293, 1993.

Storage Conditions

At -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freezing and thawing.