DT-3

DT-3 is a cell-permeable peptide inhibitor that selectively targets and inhibits cGMP-dependent protein kinase G Iα (PKG Iα) and guanylyl cyclase, thereby blocking the downstream cGMP-PKG signaling cascade. This tool compound is widely used in cardiovascular, neurological, and smooth muscle research, with applications in both in vitro assays and in vivo animal models to study nitric oxide and natriuretic peptide signaling pathways.