Anti-PAX1 Antibody Picoband®, PE Conjugate

Boster Bio Anti-PAX1 Antibody Picoband® catalog # A04559-2. Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Product Specifications

Background

This gene is a member of the paired box (PAX) family of transcription factors. Members of the PAX family typically contain a paired box domain and a paired-type homeodomain. These genes play critical roles during fetal development. This gene plays a role in pattern formation during embryogenesis and may be essential for development of the vertebral column. This gene is silenced by methylation in ovarian and cervical cancers and may be a tumor suppressor gene. Mutations in this gene are also associated with vertebral malformations.

Synonyms

Lymphotactin; C motif chemokine 1; Cytokine SCM-1; Lymphotaxin; Small-inducible cytokine C1; Xcl1; Lptn; Ltn; Scyc1

Gene Name

chemokine (C motif) ligand 1

Gene ID

5075

UniProt

P15863

Host

Rabbit

Reactivity

Human,Mouse,Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human PAX1 recombinant protein (Position: S218-P382).

Clonality

Polyclonal

Tissue Specificity

Expressed in activated CD8 (+) T cells. In the thymus, expressed by medullary thymic epithelial cells.

Applications

WB,Flow Cytometry,ELISA

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Chemotactic activity for lymphocytes but not for monocytes or neutrophils. In thymus, mediates medullary accumulation of thymic dendritic cells and contributes to regulatoy T cell development, playing a role in self-tolerance establishment.

Components

Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.01mg NaN3.

References & Citations

1. Hol, F. A., Geurds, M. P. A., Chatkupt, S., Shugart, Y. Y., Balling, R., Schrander-Stumpel, C. T. R. M., Johnson, W. G., Hamel, B. C. J., Mariman, E. C. M. PAX genes and human neural tube defects: an amino acid substitution in PAX1 in a patient with spina bifida. J. Med. Genet. 33: 655-660, 1996. 2. McGaughran, J. M., Oates, A., Donnai, D., Read, A. P., Tassabehji, M. Mutations in PAX1 may be associated with Klippel-Feil syndrome. Europ. J. Hum. Genet. 11: 468-474, 2003. 3. Pohl, E., Aykut, A., Beleggia, F., Karaca, E., Durmaz, B., Keupp, K., Arslan, E., Palamar, M., Yigit, G., Ozkinay, F., Wollnik, B. A hypofunctional PAX1 mutation causes autosomal recessively inherited otofaciocervical syndrome. Hum. Genet. 132: 1311-1320, 2013. Note: Erratum: Hum. Genet. 132: 1321 only, 2013.

Storage Conditions

Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.