Tubulin polymerization-IN-55
Tubulin polymerization-IN-55 is a potent inhibitor of Tubulin Polymerization. Tubulin polymerization-IN-55 has antiproliferative activity against A549, K562, HepG2, MDA-MB-231 and HFL-1 with IC50 s of 8, 3, 9, 24 and 62 nM, respectively[1].
Product Specifications
CAS Number
2942396-29-2
UNSPSC
12352005
Target
Microtubule/Tubulin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tubulin-polymerization-in-55.html
Purity
98.84
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1C2=C(C(OC)=C(C=C2N(CC1)C3=CC(C=CN4CC)=C4C=C3)OC)OC
Molecular Formula
C22H24N2O4
Molecular Weight
380.44
References & Citations
[1]Tan Y, et al. Design, synthesis and biological evaluation of novel dihydroquinolin-4 (1H) -one derivatives as novel tubulin polymerization inhibitors. Eur J Med Chem. 2023 Oct 15;262:115881.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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