Tubulin polymerization-IN-55

Tubulin polymerization-IN-55 is a potent inhibitor of Tubulin Polymerization. Tubulin polymerization-IN-55 has antiproliferative activity against A549, K562, HepG2, MDA-MB-231 and HFL-1 with IC50 s of 8, 3, 9, 24 and 62 nM, respectively[1].

Product Specifications

CAS Number

[2942396-29-2]

UNSPSC

12352005

Target

Microtubule/Tubulin

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tubulin-polymerization-in-55.html

Purity

98.84

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1C2=C(C(OC)=C(C=C2N(CC1)C3=CC(C=CN4CC)=C4C=C3)OC)OC

Molecular Formula

C22H24N2O4

Molecular Weight

380.44

References & Citations

[1]Tan Y, et al. Design, synthesis and biological evaluation of novel dihydroquinolin-4 (1H) -one derivatives as novel tubulin polymerization inhibitors. Eur J Med Chem. 2023 Oct 15;262:115881.