Anti-PTCRA Antibody Picoband®, PE Conjugate

Boster Bio Anti-PTCRA Antibody Picoband® catalog # A10240-1. Tested in ELISA, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Product Specifications

Background

This PTCRA gene is mapped to 6p21.1. The protein encoded by this gene is a single-pass type I membrane protein that is found in immmature but not mature T-cells. Along with TCRB and CD3 complex, the encoded protein forms the pre-T-cell receptor complex, which regulates early T-cell development. Four transcript variants encoding different isoforms have been found for this gene.

Synonyms

Pre T-cell antigen receptor alpha; pT-alpha; pTa; pT-alpha-TCR; PTCRA

Gene Name

pre T cell antigen receptor alpha

Gene ID

171558

UniProt

Q6ISU1

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived human PTCRA recombinant protein (Position: T24-T143).

Clonality

Polyclonal

Tissue Specificity

Expressed in immature but not mature T-cells. Also found in CD34+ cells from peripheral blood, CD34+ precursors from umbilical cord blood and adult bone marrow.

Applications

ELISA,WB

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

The pre-T-cell receptor complex (composed of PTCRA, TCRB and the CD3 complex) regulates early T-cell development. .

Components

Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

References & Citations

1. Aifantis, I., Borowski, C., Gounari, F., Lacorazza, H. D., Nikolich-Zugich, J., von Boehmer, H. A critical role for the cytoplasmic tail of pT-alpha in T lymphocyte development. Nature Immun. 3: 483-488, 2002. Note: Erratum: Nature Immun. 3: 591 only, 2002. 2. Del Porto, P., Bruno, L., Mattei, M.-G., von Boehmer, H., Saint-Ruf, C. Cloning and comparative analysis of the human pre-T-cell receptor alpha-chain gene. Proc. Nat. Acad. Sci. 92: 12105-12109, 1995. 3. Saint-Ruf, C., Lechner, O., Feinberg, J., von Boehmer, H. Genomic structure of the human pre-T cell receptor alpha chain and expression of two mRNA isoforms. Europ. J. Immun. 28: 3824-3831, 1998.

Storage Conditions

Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.