WEE1 degrader 1
WEE1 degrader 1 (Compound 10) is a Wee1 degrader with a DC50 value of 1.5 nM against Wee1. WEE1 degrader 1 possesses anti-cancer cell proliferation effects[1].
Product Specifications
UNSPSC
12352211
Target
Wee1
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/wee1-degrader-1.html
Purity
99.74
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1N(C2CCC(NC2=O)=O)CC3=C1C=CC(C4=C(N[C@@]56CC(CC(C6)C7)CC7C5)N8C(C=CC=C8)=N4)=C3
Molecular Formula
C30H31N5O3
Molecular Weight
509.60
References & Citations
[1]Razumkov H, et al. Discovery of CRBN-dependent WEE1 molecular glue degraders from a multicomponent combinatorial library[J]. Journal of the American Chemical Society, 2024.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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