WEE1 degrader 1

WEE1 degrader 1 (Compound 10) is a Wee1 degrader with a DC50 value of 1.5 nM against Wee1. WEE1 degrader 1 possesses anti-cancer cell proliferation effects[1].

Product Specifications

UNSPSC

12352211

Target

Wee1

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/wee1-degrader-1.html

Purity

99.74

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1N(C2CCC(NC2=O)=O)CC3=C1C=CC(C4=C(N[C@@]56CC(CC(C6)C7)CC7C5)N8C(C=CC=C8)=N4)=C3

Molecular Formula

C30H31N5O3

Molecular Weight

509.60

References & Citations

[1]Razumkov H, et al. Discovery of CRBN-dependent WEE1 molecular glue degraders from a multicomponent combinatorial library[J]. Journal of the American Chemical Society, 2024.