Barbadin
Barbadin is a novel and selective β-arrestin/β2-adaptin interaction inhibitor, has IC50 values of 19.1 μM for β-arrestin1 and 15.6 μM for β-arrestin2. Barbadin blocks agonist-promoted endocytosis of the prototypical β2-adrenergic, V2-vasopressin and angiotensin-II type-1 receptors. Barbadin can induce apoptosis[1][2].
Product Specifications
CAS Number
356568-70-2
UNSPSC
12352005
Target
Apoptosis; Arrestin
Type
Reference compound
Related Pathways
Apoptosis; GPCR/G Protein
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/barbadin.html
Purity
98.93
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C1C(C(C2=CC=C(CC3=CC=CC=C3)C=C2)=CS4)=C4N=CN1N
Molecular Formula
C19H15N3OS
Molecular Weight
333.41
References & Citations
[1]Beautrait A, et al. A new inhibitor of the β-arrestin/AP2 endocytic complex reveals interplay between GPCR internalization and signalling. Nat Commun. 2017 Apr 18;8:15054. doi: 10.1038/ncomms15054.|[2]Thoria Donia, et al. β-Arrestin inhibition induces autophagy, apoptosis, G0/G1 cell cycle arrest in agonist-activated V2R receptor in breast cancer cells. Med Oncol. 2021 Mar 15;38 (4) :38.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Arrestin-3/β-Arrestin 2
Available Sizes
Frequently Asked Questions
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