Barbadin

Barbadin is a novel and selective β-arrestin/β2-adaptin interaction inhibitor, has IC50 values of 19.1 μM for β-arrestin1 and 15.6 μM for β-arrestin2. Barbadin blocks agonist-promoted endocytosis of the prototypical β2-adrenergic, V2-vasopressin and angiotensin-II type-1 receptors. Barbadin can induce apoptosis[1][2].

Product Specifications

CAS Number

[356568-70-2]

UNSPSC

12352005

Target

Apoptosis; Arrestin

Type

Reference compound

Related Pathways

Apoptosis; GPCR/G Protein

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/barbadin.html

Purity

98.93

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C1C(C(C2=CC=C(CC3=CC=CC=C3)C=C2)=CS4)=C4N=CN1N

Molecular Formula

C19H15N3OS

Molecular Weight

333.41

References & Citations

[1]Beautrait A, et al. A new inhibitor of the β-arrestin/AP2 endocytic complex reveals interplay between GPCR internalization and signalling. Nat Commun. 2017 Apr 18;8:15054. doi: 10.1038/ncomms15054.|[2]Thoria Donia, et al. β-Arrestin inhibition induces autophagy, apoptosis, G0/G1 cell cycle arrest in agonist-activated V2R receptor in breast cancer cells. Med Oncol. 2021 Mar 15;38 (4) :38.