Phlotoxin-1

Phlotoxin-1 (PhlTx1) is a 34-residue, three-disulfide-bridged peptide toxin isolated from Phlogiellus spiders. It functions as a potent and selective inhibitor of the voltage-gated sodium channel NaV1.7, demonstrating antinociceptive effects. This makes it a valuable research tool for studying pain pathways in both in vitro and in vivo models.