NNMT-IN-6
NNMT-IN-6 (compound 78) is a potent nicotinamide N-methyltransferase (NNMT) inhibitor with an IC50 of 1.41 μM and a Kd of 5.6 μM. NNMT-IN-6 shows an inhibitory effect on the cell proliferation of the HSC-2 human oral cancer cell line[1].
Product Specifications
CAS Number
2368247-39-4
UNSPSC
12352005
Target
Amine N-methyltransferase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nnmt-in-6.html
Smiles
NC1=NC=NC2=C1N=CN2[C@H]3[C@H](O)[C@H](O)[C@@H](CN(CC(C=C4)=CC5=C4C=CC=C5)CC[C@@H](C(O)=O)N)O3
Molecular Formula
C25H29N7O5
Molecular Weight
507.54
References & Citations
[1]Gao Y, et al. Bisubstrate Inhibitors of Nicotinamide N-Methyltransferase (NNMT) with Enhanced Activity. J Med Chem. 2019 Jul 25;62 (14) :6597-6614.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
Pyruvate Kinase (PKLR) (C-term) Rabbit Polyclonal Antibody
![Elab Fluor® 488 Anti-Mouse Perforin Antibody[S16009A]](https://cdn.genprice.uk/products/763/68dd149f061270361e7d021e/imageurl/e-ab-f1294ul.webp)