AN0128

AN0128 is a boron-containing antibacterial and anti-inflammatory agent. AN0128 against S. aureus, S. epidermidis, P. acnes, B. subtilis with minimum inhibitory concentration (MIC) values of 1, 0.5, 0.3, 1 μg/mL. AN0128 can be used for the research of periodontal disease and cutaneous diseases[1][2].

Product Specifications

CAS Number

[872044-70-7]

UNSPSC

12352005

Target

Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/an0128.html

Purity

98.95

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

OC1=CC=CN=C1C(OB(C2=CC(Cl)=C(C)C=C2)C3=CC(Cl)=C(C)C=C3)=O

Molecular Formula

C20H16BCl2NO3

Molecular Weight

400.06

References & Citations

[1]Baker SJ, et al. Identification of a novel boron-containing antibacterial agent (AN0128) with anti-inflammatory activity, for the potential treatment of cutaneous diseases. Bioorg Med Chem Lett. 2006 Dec 1;16 (23) :5963-7.|[2]Luan Q, et al. Inhibition of experimental periodontitis by a topical boron-based antimicrobial. J Dent Res. 2008 Feb;87 (2) :148-52.