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Activin A, Human/Mouse/Rat (HEK293)

Activin A, a multifunctional cytokine, is a member of TGF-β superfamily. Activin A first binds to the type II activin receptors (ActIIRA or ActRIIB) on the member surface, and then recruits and phosphorylates type I activin receptors (ActRI) . Activin A primarily signal through SMAD2/3 proteins to regulate a variety of functions, including inflammation, fibrosis, and tumorigenesis[1]. Activin A Protein, Human/Mouse/Rat (HEK293) is produced in HEK293 cells, and consists of 117 amino acids (G310-S426) .

Product Specifications

Product Name Alternative

Activin A Protein, Human/Mouse/Rat (HEK293), Rat; Mouse; Human, HEK293

UNSPSC

12352202

Type

Recombinant Proteins

Related Pathways

Stem Cell/Wnt

Assay Protocol

https://www.medchemexpress.com/cytokines/activin-a-protein-human-mouse-rat-hek293.html

Purity

98.00

Smiles

GLECDGKVNICCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIAGTSGSSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLRPMSMLYYDDGQNIIKKDIQNMIVEECGCS

Molecular Formula

3624 (Gene_ID) P08476 (G311-S426) (Accession)

Molecular Weight

Approximately 15 kDa, based on SDS-PAGE under reducing conditions.

References & Citations

[1]Ge J, et al. Involvement of CHOP in activin A induced myeloma NS 1 cell apoptosis. Oncol Rep. 2019;42 (6) :2644-2654.|[2]Enrrico Bloise, et al. Activin A in Mammalian Physiology. Physiol Rev. 2019 Jan 1;99 (1) :739-780.|[3]N L Frigon Jr, et al. Regulation of globin gene expression in human K562 cells by recombinant activin A. Blood. 1992 Feb 1;79 (3) :765-72.|[4]D D Wu, et al. Expression of the activin axis and neuronal rescue effects of recombinant activin A following hypoxic-ischemic brain injury in the infant rat. Brain Res. 1999 Jul 24;835 (2) :369-78.|[5]B Attardi, et al. Rapid stimulatory effect of activin-A on messenger RNA encoding the follicle-stimulating hormone beta-subunit in rat pituitary cell cultures. Mol Endocrinol. 1990 May;4 (5) :721-6.

Shipping Conditions

Room temperature in continental US; may vary elsewhere.

Storage Conditions

Stored at -20°C for 2 years

Scientific Category

Recombinant Proteins

Available Sizes

Frequently Asked Questions

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