[Glu2]-TRH

(Glu2) -TRH, a metabolically stable analogue of Thyrotropin-releasing hormone (TRH; HY-P0002), is a negative modulator for the cholinergic effect of TRH in the mouse brain. (Glu2) -TRH significantly attenuates TRH-induced hippocampal extracellular acetylcholine release. (Glu2) -TRH is not metabolized by thyroliberinase. (Glu2) -TRH manifests neuroprotective, antidepressant, anticonvulsant in the CNS.