Fenretinide

Fenretinide (4-HPR) is a synthetic retinoid deriverative, binding to the retinoic acid receptors (RAR) at concentrations necessary to induce cell death.

Product Specifications

CAS Number

[65646-68-6]

Product Name Alternative

4-HPR; ISLA-101

UNSPSC

12352005

Hazard Statement

H302+H312+H332, H315, H319, H335, H360

Target

Autophagy; RAR/RXR

Type

Reference compound

Related Pathways

Autophagy; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Fenretinide.html

Purity

99.15

Solubility

DMSO : ≥ 100 mg/mL

Smiles

CC(/C=C/C=C(/C=C/C1=C(CCCC(C)1C)C)C)=C\C(NC2=CC=C(O)C=C2)=O

Molecular Formula

C26H33NO2

Molecular Weight

391.55

Precautions

H302+H312+H332, H315, H319, H335, H360

References & Citations

[1]Apraiz, Aintzane., et al. Dihydroceramide accumulation and reactive oxygen species are distinct and nonessential events in 4-HPR-mediated leukemia cell death. Biochemistry and Cell Biology (2012), 90 (2), 209-223.|[2]Bikman, Benjamin T., et al. Fenretinide Prevents Lipid-induced Insulin Resistance by Blocking Ceramide Biosynthesis. Journal of Biological Chemistry (2012), 287 (21), 17426-17437.|[3]Cooper JP, et al. Fenretinide metabolism in humans and mice: utilizing pharmacological modulation of its metabolic pathway to increase systemic exposure. Br J Pharmacol. 2011 Jul;163 (6) :1263-75.|[4]Golubkov V, et al. Action of fenretinide (4-HPR) on ovarian cancer and endothelial cells. Anticancer Res. 2005 Jan-Feb;25 (1A) :249-53.