Purvalanol B
Purvalanol B (NG 95) is a potent, selective, reversible and ATP-competitive inhibitor CDK, with IC50s of 6 nM, 6 nM, 9 nM, 6 nM for cdc2-cyclin B, CDK2-cyclin A, CDK2-cyclin E and CDK5-p35, respectively. Purvalanol B shows selectivity for CDK over a range of other protein kinases (IC50>1000 nM) . Purvalanol B inhibits the growth a chloroquine-resistant strain of P. falciparum[1][1].
Product Specifications
CAS Number
212844-54-7
Product Name Alternative
NG 95
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
CDK; Parasite
Type
Reference compound
Related Pathways
Anti-infection; Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/Purvalanol-B.html
Purity
97.0
Solubility
DMSO : ≥ 40 mg/mL
Smiles
O=C(O)C1=CC=C(NC2=C3N=CN(C(C)C)C3=NC(N[C@@H](CO)C(C)C)=N2)C=C1Cl
Molecular Formula
C20H25ClN6O3
Molecular Weight
432.90
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK1; CDK2; CDK5
Available Sizes
Frequently Asked Questions
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