KH-CB20
KH-CB20, an E/Z mixture, is a potent and selective inhibitor of CLK1 and the closely related isoform CLK4, with an IC50 of 16.5 nM for CLK1. KH-CB20 can also inhibit DYRK1A (IC50=57.8 nM) and CLK3 (IC50=488 nM) [1].
Product Specifications
CAS Number
1354448-60-4
UNSPSC
12352005
Target
CDK; DYRK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Infection; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/kh-cb20.html
Purity
99.80
Solubility
DMSO : 100 mg/mL (ultrasonic; warming)
Smiles
CCOC(C1=C(C2=C(C(Cl)=C(C=C2)Cl)N1C)/C(C#N)=C\N)=O
Molecular Formula
C15H13Cl2N3O2
Molecular Weight
338.19
References & Citations
[1]Fedorov O, et, al. Specific CLK inhibitors from a novel chemotype for regulation of alternative splicing. Chem Biol. 2011 Jan 28;18 (1) :67-76.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CLK; DYRK1
Available Sizes
Frequently Asked Questions
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