β-1,3-Glucan

β-1,3-Glucan (β Glucan) is an orally active polysaccharide composed of glucose polymers. β-1,3-Glucan increase the activity of IKKβ kinase, enhances the production of nitric oxide. β-1,3-Glucan improves resistance to Vibrio harveyi infection. β-1,3-Glucan enhances immune response, promotes blood pressure recovery, reduces lung, kidney and liver damage, inhibits the growth of syngeneic tumors[1][2][3][4][5][6][7][8].

Product Specifications

CAS Number

[9051-97-2]

Product Name Alternative

β Glucan

UNSPSC

12352200

Hazard Statement

H302, H315, H319, H335

Target

Bacterial; Biochemical Assay Reagents; IKK; NO Synthase

Type

Biochemical Assay Reagents

Related Pathways

Anti-infection; Immunology/Inflammation; NF-κB; Others

Field of Research

Cancer; Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/β-1-3-glucan.html

Solubility

DMSO : 5 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 40 mg/mL (adjust pH to 12 with 1 M NaOH)

Smiles

[betaGlucan]

Precautions

H302, H315, H319, H335

References & Citations

[1]Wakshull E, et al. PGG-glucan, a soluble beta- (1,3) -glucan, enhances the oxidative burst response, microbicidal activity, and activates an NF-kappa B-like factor in human PMN: evidence for a glycosphingolipid beta- (1,3) -glucan receptor. Immunopharmacology. 1999 Feb;41 (2) :89-107.|[2]Ai Q, et al. Effects of dietary beta-1, 3 glucan on innate immune response of large yellow croaker, Pseudosciaena crocea. Fish Shellfish Immunol. 2007 Apr;22 (4) :394-402.|[3]Son H J, et al. Effects of β-glucan on proliferation and migration of fibroblasts. Current Applied Physics, 2005, 5 (5) : 468-471.|[4]Suzuki I, et al. Immunomodulation by orally administered β-glucan in mice. International journal of immunopharmacology, 1989, 11 (7) : 761-769.|[5]Sandvik A, et al. Oral and systemic administration of beta-glucan protects against lipopolysaccharide-induced shock and organ injury in rats. Clin Exp Immunol. 2007 Apr;148 (1) :168-77.|[6]Bedirli A, et al. Beta-glucan attenuates inflammatory cytokine release and prevents acute lung injury in an experimental model of sepsis. Shock. 2007 Apr;27 (4) :397-401.|[7]Torello CO, et al. β-1,3-Glucan given orally modulates immunomyelopoietic activity and enhances the resistance of tumour-bearing mice. Clin Exp Pharmacol Physiol. 2012 Mar;39 (3) :209-17.|[8]Bakheet SA, et al. β-1,3-Glucan reverses aflatoxin B1-mediated suppression of immune responses in mice. Life Sci. 2016 May 1;152:1-13.