CGAS-IN-1
CGAS-IN-1 (Compound C20) is a cyclic GMP-AMP synthase (cGAS) inhibitor with IC50s of 2.28 μM (human cGAS, h-cGASFL) and 1.44 μM (mouse cGAS, m-cGASCD) . cGAS-IN-1 can be used for the studies of autoimmune diseases and chronic inflammation[1].
Product Specifications
CAS Number
[858770-07-7]
UNSPSC
12352005
Target
Cyclic GMP-AMP Synthase
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/cgas-in-1.html
Purity
98.29
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
COC1=CC2=C(C(C)=C(CCC(N(CC(O)=O)CC(O)=O)=O)C(O2)=O)C=C1
Molecular Formula
C18H19NO8
Molecular Weight
377.35
References & Citations
[1]Li J, et al. Discovery of novel cGAS inhibitors based on natural flavonoids. Bioorg Chem. 2023 Nov;140:106802.. .
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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