cGAS-IN-1
Product Specifications
UNSPSC Description
cGAS-IN-1 (compound C20) is a flavonoid and Cyclic GMP-AMP Synthase (cGAS) inhibitor with IC50s of 2.28 μM (human cGAS) and 1.44 μM (mouse cGAS). Abnormal activation of cGAS is associated with a variety of immune-mediated inflammatory diseases, and cGAS-IN-1 has potential anti-inflammatory activity[1].
Target Antigen
Cyclic GMP-AMP Synthase
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/cgas-in-1.html
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
COC1=CC2=C(C(C)=C(CCC(N(CC(O)=O)CC(O)=O)=O)C(O2)=O)C=C1
Molecular Weight
377.35
References & Citations
[1]Li J, et al. Discovery of novel cGAS inhibitors based on natural flavonoids. Bioorg Chem. 2023 Nov;140:106802.. .
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-149526/cGAS-IN-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-149526/cGAS-IN-1-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
858770-07-7
Available Sizes
Curated Selection
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