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CGAS-IN-1

CGAS-IN-1 (Compound C20) is a cyclic GMP-AMP synthase (cGAS) inhibitor with IC50s of 2.28 μM (human cGAS, h-cGASFL) and 1.44 μM (mouse cGAS, m-cGASCD) . cGAS-IN-1 can be used for the studies of autoimmune diseases and chronic inflammation[1].

Product Specifications

CAS Number

[858770-07-7]

UNSPSC

12352005

Target

Cyclic GMP-AMP Synthase

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/cgas-in-1.html

Purity

98.29

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

COC1=CC2=C(C(C)=C(CCC(N(CC(O)=O)CC(O)=O)=O)C(O2)=O)C=C1

Molecular Formula

C18H19NO8

Molecular Weight

377.35

References & Citations

[1]Li J, et al. Discovery of novel cGAS inhibitors based on natural flavonoids. Bioorg Chem. 2023 Nov;140:106802.. .

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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