CGAS-IN-1
CGAS-IN-1 (Compound C20) is a cyclic GMP-AMP synthase (cGAS) inhibitor with IC50s of 2.28 μM (human cGAS, h-cGASFL) and 1.44 μM (mouse cGAS, m-cGASCD) . cGAS-IN-1 can be used for the studies of autoimmune diseases and chronic inflammation[1].
Product Specifications
CAS Number
[858770-07-7]
UNSPSC
12352005
Target
Cyclic GMP-AMP Synthase
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/cgas-in-1.html
Purity
98.29
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
COC1=CC2=C(C(C)=C(CCC(N(CC(O)=O)CC(O)=O)=O)C(O2)=O)C=C1
Molecular Formula
C18H19NO8
Molecular Weight
377.35
References & Citations
[1]Li J, et al. Discovery of novel cGAS inhibitors based on natural flavonoids. Bioorg Chem. 2023 Nov;140:106802.. .
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Explore Other Products
Browse additional items from our catalog
Human Endoplasmic Reticulum Resident Protein 57 (ERp57) ELISA Kit
Human Endoplasmic Reticulum Resident Protein 57 (ERp57) ELISA Kit
