Izuforant

Izuforant (JW1601) (Compound 24) is an orally active histamine H4 receptor (H4R) antagonist with an IC50 of 36 nM against human H4R. Izuforant also shows binding affinity of human serotonin 3 receptor (h5-HT3R) with an IC50 of 9.1 μM. Izuforant exhibits strong anti-pruritic and anti-inflammatory efficacies[1][2].

Product Specifications

CAS Number

[1429374-83-3]

Product Name Alternative

JW1601

UNSPSC

12352005

Target

Histamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/izuforant.html

Purity

98.88

Solubility

DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CNC1CN(C2=NC3=NC=C(Br)C=C3N4C2=NN=C4)C1

Molecular Formula

C12H12BrN7

Molecular Weight

334.17

References & Citations

[1]Pil Su Ho, et al. Novel heterocyclic derivatives and their uses. WO2013048214A2.|[2]Jin M, et al. From Bench to Clinic: the Potential of Therapeutic Targeting of the IL-22 Signaling Pathway in Atopic Dermatitis. Immune Netw. 2018 Dec 19;18 (6) :e42.