Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-CSEN/KCNIP3 Antibody Picoband® (Dylight488 Conjugate)

Boster Bio Anti-CSEN/KCNIP3 Antibody catalog # PA2272. Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Product Specifications

Background

KCNIP3, also known as Calsenilin, is a calcium-dependent transcriptional repressor that is highly expressed in central nervous system, thyroid gland, testis, thymus, and immune cells. This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the neuronal calcium sensor family of proteins. KCNIP3 is mapped to 2q11.1. The encoded protein functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. KCNIP3-regulated genes have a critical function in Ig subclass production and proliferation in B lymphocytes. KCNIP3 has been shown to interact with PSEN1 and PSEN2.

Synonyms

Calsenilin;A-type potassium channel modulatory protein 3;DRE-antagonist modulator;DREAM;Kv channel-interacting protein 3;KChIP3;KCNIP3;CSEN, DREAM, KCHIP3;

Gene Name

Calsenilin

UniProt

Q9Y2W7

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human CSEN.

Clonality

Polyclonal

Tissue Specificity

Highly expressed in brain. Widely expressed at lower levels. Expression levels are elevated in brain cortex regions affected by Alzheimer disease. .

Applications

WB

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Calcium-dependent transcriptional repressor that binds to the DRE element of genes including PDYN and FOS. Affinity for DNA is reduced upon binding to calcium and enhanced by binding to magnesium. Seems to be involved in nociception (By similarity). .

Storage Conditions

Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=PA2272

Product MSDS

https://www.bosterbio.com/msds?sku=PA2272

Fragment

Rabbit IgG

Applications Notes

Western blot, 0.1-0.5μg/ml, Human<br>

Subcellular Location

Cytoplasm . Cell membrane ; Lipid-anchor . Endoplasmic reticulum . Golgi apparatus. Nucleus. Also membrane-bound, associated with the plasma membrane (PubMed:15485870). In the presence of PSEN2 associated with the endoplasmic reticulum and Golgi. The sumoylated form is present only in the nucleus. .

Sequence Similarities

Belongs to the recoverin family.

Protein Name

Calsenilin

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

Pcdha4 Mouse siRNA Oligo Duplex (Locus ID 12936)
SR418561 1 Kit

Pcdha4 Mouse siRNA Oligo Duplex (Locus ID 12936)

Ask
View Details
DHX16 Human qPCR Primer Pair (NM_003587)
HP207081 200 Reactions

DHX16 Human qPCR Primer Pair (NM_003587)

Ask
View Details
Rps6ka5 (NM_153587) Mouse Tagged ORF Clone Lentiviral Particle
MR210996L3V 200 µL

Rps6ka5 (NM_153587) Mouse Tagged ORF Clone Lentiviral Particle

Ask
View Details
Recombinant Mouse GTP-binding protein Rhes (Rasd2)
MBS965258-01 0.02 mg (E-Coli)

Recombinant Mouse GTP-binding protein Rhes (Rasd2)

Ask
View Details
Recombinant Mouse GTP-binding protein Rhes (Rasd2)
MBS965258-02 0.02 mg (Yeast)

Recombinant Mouse GTP-binding protein Rhes (Rasd2)

Ask
View Details
Recombinant Mouse GTP-binding protein Rhes (Rasd2)
MBS965258-03 0.1 mg (E-Coli)

Recombinant Mouse GTP-binding protein Rhes (Rasd2)

Ask
View Details