7-Aminomethyl-10-methyl-11-fluoro camptothecin

7-Aminomethyl-10-methyl-11-fluoro camptothecin is a cytotoxin of MC-AAA-NHCH2OCH2COO-7-aminomethyl-10-methyl-11-fluoro camptothecin (HY-132158) . 7-Aminomethyl-10-methyl-11-fluoro camptothecin can be used for the synthesis of camptothecin antibody-drug conjugate (ADC) [1].

Product Specifications

CAS Number

[2378616-23-8]

UNSPSC

12352203

Hazard Statement

H301-H340

Target

ADC Payload

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/7-aminomethyl-10-methyl-11-fluoro-camptothecin.html

Purity

99.30

Solubility

DMSO : 60 mg/mL (ultrasonic)

Smiles

NCC1=C2C(C(N3C2)=CC([C@]4(CC)O)=C(C3=O)COC4=O)=NC5=CC(F)=C(C=C51)C

Molecular Formula

C22H20FN3O4

Molecular Weight

409.41

Precautions

P264-P270-P280-P330-P405-P501

References & Citations

[1]Li W, et, al. Synthesis and Evaluation of Camptothecin Antibody-Drug Conjugates. ACS Med Chem Lett. 2019 Sep 6;10 (10) :1386-1392.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, sealed storage, away from moisture and light)

Scientific Category

ADC Related

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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