Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-PDCD4 Antibody Picoband® (Dylight488 Conjugate)

Boster Bio Anti-PDCD4 Antibody Picoband® catalog # A01105-4. Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Product Specifications

Background

Programmed cell death protein 4 (PDCD4) is a protein that in humans is encoded by the PDCD4 gene. It is mapped to 10q25.2. This gene is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. It also encodes a protein localized to the nucleus in proliferating cells. Expression of this gene is modulated by cytokines in natural killer and T cells. The gene product is thought to play a role in apoptosis but the specific role has not yet been determined.

Synonyms

Programmed cell death protein 4;Neoplastic transformation inhibitor protein;Nuclear antigen H731-like;Protein 197/15a;PDCD4;H731;

Gene Name

Programmed cell death protein 4

UniProt

Q53EL6

Host

Rabbit

Reactivity

Human,Mouse,Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human PDCD4 recombinant protein (Position: D160-L363).

Clonality

Polyclonal

Tissue Specificity

Up-regulated in proliferative cells. Highly expressed in epithelial cells of the mammary gland. Reduced expression in lung cancer and colon carcinoma. .

Applications

WB,ELISA

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Function

Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity). .

Storage Conditions

At -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freezing and thawing.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A01105-4

Product MSDS

https://www.bosterbio.com/msds?sku=A01105-4

Fragment

Rabbit IgG

Applications Notes

Western blot, 0.1-0.25 μg/ml, Human, Mouse, Rat<br> ELISA, 0.1-0.5 μg/ml, -<br>

Subcellular Location

Nucleus. Cytoplasm. Shuttles between the nucleus and cytoplasm. Predominantly nuclear under normal growth conditions, and when phosphorylated at Ser-457. Exported from the nucleus in the absence of serum.

Protein Name

Putative Polycomb group protein ASXL1

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

SµLfatase 2 (SµLF2) Human shRNA Lentiviral Particle (Locus ID 55959)
TL301311V 500 µL Each

SµLfatase 2 (SµLF2) Human shRNA Lentiviral Particle (Locus ID 55959)

Ask
View Details
KLHL23 (NM_144711) Human Untagged Clone
SC310269 10 µg

KLHL23 (NM_144711) Human Untagged Clone

Ask
View Details
Anti-Tryptase (Mast Cell Marker)(TPSAB1/1963), CF594 conjugate
BNC941963-500 500 µL

Anti-Tryptase (Mast Cell Marker)(TPSAB1/1963), CF594 conjugate

Ask
View Details
PAK4 3'UTR Lenti-reporter-Luc Vector
35962081 1.0 μg

PAK4 3'UTR Lenti-reporter-Luc Vector

Ask
View Details
Mouse Anti-PRF1 Antibody, FITC (MOFAB-350W)
MOFAB-350W Each

Mouse Anti-PRF1 Antibody, FITC (MOFAB-350W)

Ask
View Details