1,2-Dihydrotanshinone
1,2-Dihydrotanshinone (1,2-Dihydrotanshinquinone) is an abietane diterpene. 1,2-Dihydrotanshinone inhibits the formation of the pathogenic complex formed between (CUG) n-RNA and the splicing-factor muscleblind-like 1 (MBNL1) . 1,2-Dihydrotanshinone can be used for the research of myotonic dystrophy type 1[1][2].
Product Specifications
CAS Number
[77769-21-2]
Product Name Alternative
1,2-Dihydrotanshinquinone
UNSPSC
12352005
Target
DNA/RNA Synthesis
Type
Natural Products
Related Pathways
Cell Cycle/DNA Damage
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/1-2-dihydrotanshinone.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=C2C=CC3=C1CCC=C3C)C(C4=C2OC=C4C)=O
Molecular Formula
C18H14O3
Molecular Weight
278.30
References & Citations
[1]Faleschini MT, et, al. Discovery of natural products potentially active against myotonic dystrophy type 1. Planta Med 2015; 81-YRW_03.|[2]Fronza M, et, al. In vitro cytotoxic activity of abietane diterpenes from Peltodon longipes as well as Salvia miltiorrhiza and Salvia sahendica. Bioorg Med Chem. 2011 Aug 15;19 (16) :4876-81.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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