1,2-Dihydrotanshinone

1,2-Dihydrotanshinone (1,2-Dihydrotanshinquinone) is an abietane diterpene. 1,2-Dihydrotanshinone inhibits the formation of the pathogenic complex formed between (CUG) n-RNA and the splicing-factor muscleblind-like 1 (MBNL1) . 1,2-Dihydrotanshinone can be used for the research of myotonic dystrophy type 1[1][2].

Product Specifications

CAS Number

[77769-21-2]

Product Name Alternative

1,2-Dihydrotanshinquinone

UNSPSC

12352005

Target

DNA/RNA Synthesis

Type

Natural Products

Related Pathways

Cell Cycle/DNA Damage

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/1-2-dihydrotanshinone.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=C2C=CC3=C1CCC=C3C)C(C4=C2OC=C4C)=O

Molecular Formula

C18H14O3

Molecular Weight

278.30

References & Citations

[1]Faleschini MT, et, al. Discovery of natural products potentially active against myotonic dystrophy type 1. Planta Med 2015; 81-YRW_03.|[2]Fronza M, et, al. In vitro cytotoxic activity of abietane diterpenes from Peltodon longipes as well as Salvia miltiorrhiza and Salvia sahendica. Bioorg Med Chem. 2011 Aug 15;19 (16) :4876-81.