Anti-Eotaxin/Ccl11 Antibody (Dylight488 Conjugate)

Boster Bio Anti-Eotaxin/Ccl11 Antibody Picoband® catalog # A01438-2. Tested in ELISA, IHC applications. This antibody reacts with Rat.

Product Specifications

Background

CCL11 (Chemokine (C-C motif) ligand 11), also known as Eotaxin, is a small cytokine belonging to the CC chemokine family. Eotaxin selectively recruits eosinophils by inducing their chemotaxis, and therefore, is implicated in allergic responses. The effects of Eotaxin are mediated by its binding to a G-protein-linked receptor known as a chemokine receptor. Chemokine receptors for which Eotaxin is a ligand include CCR2, CCR3 and CCR5. However, it has been found that eotaxin-1 (CCL11) has high degree selectivity for its receptor, such that they are inactive on neutrophils and monocytes, which do not express CCR3. The gene for human Eotaxin is encoded on three exons and is located on chromosome 17q12.

Synonyms

Bestrophin-1; TU15B; Vitelliform macular dystrophy protein 2; BEST1; VMD2

Gene Name

bestrophin 1

UniProt

P97545

Host

Rabbit

Reactivity

Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived rat Eotaxin/Ccl11 recombinant protein (Position: H24-P97).

Clonality

Polyclonal

Tissue Specificity

Predominantly expressed in the basolateral membrane of the retinal pigment epithelium.

Applications

IHC,ELISA

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Function

Forms calcium-sensitive chloride channels. Highly permeable to bicarbonate.

Storage Conditions

At -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freezing and thawing.